{"product_id":"recombinant-human-il-17a-il-17f-heterodimer-protein-his-tagactive-pksh032619","title":"Recombinant Human IL-17A\u0026IL-17F Heterodimer Protein (His Tag)(Active) - PKSH032619","description":"\u003cp\u003eRecombinant Human IL-17A\u0026amp;IL-17F Heterodimer Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032619-10, PKSH032619-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-17A\u0026amp;IL-17F Heterodimer\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: IL-17A\/F Heterodimer; IL-17A\u0026amp;IL-17F Heterodimer\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cardiovascular; Cancer; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: Cell culture\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q16552\u0026amp;Q96PD4\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q16552\u0026amp;Q96PD4\u003c\/p\u003e\n\n\u003cp\u003eBackground: The IL-17 family include IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. The family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. All members of the IL-17 family have a similar protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape, yet they have no sequence similarity to any other known cytokines. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 93 pg\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ile20-Ala155\u0026amp;Arg31-Gln163\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 43.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 15-18 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118146257075,"sku":"PKSH032619-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118146289843,"sku":"PKSH032619-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_3d1f7d71-874e-4886-9263-8b0f850546f4.png?v=1709637042","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-17a-il-17f-heterodimer-protein-his-tagactive-pksh032619","provider":"AFSBio Inc.","version":"1.0","type":"link"}