{"product_id":"recombinant-human-il-17ra-cd217-protein-rp00273","title":"Recombinant Human IL-17RA\/CD217 Protein - RP00273","description":"\u003cp\u003eRecombinant Human IL-17RA\/CD217 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00273-10, RP00273-20, RP00273-50, RP00273-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human IL-17RA\/CD217 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu33-Trp320) of human IL17RA (Accession #NP_055154.3) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R, IL17RA, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96F46\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 23765\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. This transmembrane protein (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its ability to inhibit IL-17A induced IL-6 secretion by Hela cells. The ED50 for this effect is 0.02 0.1 μg\/mL in the presence of 10 ng\/mL recombinant human IL 17A.|2.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL17RA , His Tag at 2 μg\/mL (100 μL\/well) can bind Recombinant human IL-17A,His Tag with a linear range of 31.25-65 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLW\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198302576819,"sku":"RP00273-10","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198302609587,"sku":"RP00273-20","price":189.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198302642355,"sku":"RP00273-50","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198302675123,"sku":"RP00273-100","price":336.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2a56ce20-d20e-478b-9543-7c02ea47e596.png?v=1766960346","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-17ra-cd217-protein-rp00273","provider":"AFSBio Inc.","version":"1.0","type":"link"}