{"product_id":"recombinant-human-il-2-protein-rp01039","title":"Recombinant Human IL-2 Protein - RP01039","description":"\u003cp\u003eRecombinant Human IL-2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20ug, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01039-20, RP01039-50, RP01039-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human IL-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala21-Thr153) of human IL2 (Accession #NP_000577.2) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IL2, IL-2, TCGF, lymphokine\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P60568\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3558\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured in a cell proliferation assay using CTLL‑2 mouse T cells. The ED50 for this effect is 0.255‑1.02 ng\/mL,corresponding to a specific activity of 9.80×10^5 ~3.92×10^6 units\/mg. 2.Measured in a cell proliferation assay using HT-2 Mouse T cells. The ED50 for this effect is 0.25-0.5 ng\/mL, corresponding to a specific activity of 2.0 × 10^6 ~4.0× 10^6 units\/mg.|3.Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA Protein at 2 μg\/mL (100 μL\/well) can bind Human IL2 with a linear range of 2.75-64.64 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20ug","offer_id":45198384103603,"sku":"RP01039-20","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198384136371,"sku":"RP01039-50","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198384169139,"sku":"RP01039-100","price":280.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_8c208211-eeda-4f95-8cc2-ff9bac34302f.png?v=1766961518","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-2-protein-rp01039","provider":"AFSBio Inc.","version":"1.0","type":"link"}