{"product_id":"recombinant-human-il-22bp-il-22ra2-protein-his-tagactive-pksh033384","title":"Recombinant Human IL-22BP\/IL-22RA2 Protein (His Tag)(Active) - PKSH033384","description":"\u003cp\u003eRecombinant Human IL-22BP\/IL-22RA2 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033384-10, PKSH033384-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-22BP; IL-22RA2\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Interleukin-22 Receptor Subunit Alpha-2; IL-22 Receptor Subunit Alpha-2; IL-22R-Alpha-2; IL-22RA2; Cytokine Receptor Class-II Member 10; Cytokine Receptor Family 2 Member 10; CRF2-10; Cytokine Receptor Family Type 2 Soluble 1; CRF2-S1; Interleukin-22-Binding Protein; IL-22BP; IL22BP; ZcytoR16; IL22RA2\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: Cell culture\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q969J5\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q969J5-2\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-22 Receptor Subunit α-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. IL22RA2 functions as an IL22 antagonist and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is typically 113.2 ng\/ml in the presence of 500 ng\/mL of Recombinant Human IL-22.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Thr 22-Pro231\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 25.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 44 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43114028269747,"sku":"PKSH033384-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43114028302515,"sku":"PKSH033384-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d96a5775-3735-4cd0-986b-bc73ebf1cebd.png?v=1709550467","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-22bp-il-22ra2-protein-his-tagactive-pksh033384","provider":"AFSBio Inc.","version":"1.0","type":"link"}