{"product_id":"recombinant-human-il-23-alpha-mouse-il-12-beta-heterodimer-c-6his-pksm041396","title":"Recombinant Human IL-23 alpha \u0026 Mouse IL-12 beta Heterodimer (C-6His) - PKSM041396","description":"\u003cp\u003eRecombinant Human IL-23 alpha \u0026amp; Mouse IL-12 beta Heterodimer (C-6His)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSM041396-10, PKSM041396-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-23A \u0026amp; IL-12B\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Microbiology; Cancer; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human \u0026amp; Mouse\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9NPF7\u0026amp;P43432\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9NPF7\u0026amp;P43432\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Arg20-Pro189\u0026amp;Met23-Ser335\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 56.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 65-80 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43114018144435,"sku":"PKSM041396-10","price":226.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43114018177203,"sku":"PKSM041396-50","price":680.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a4cbd4fa-eaf8-423b-be85-3d247f67cb09.png?v=1709550282","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-23-alpha-mouse-il-12-beta-heterodimer-c-6his-pksm041396","provider":"AFSBio Inc.","version":"1.0","type":"link"}