{"product_id":"recombinant-human-il-29-protein-pdmh100027","title":"Recombinant Human IL-29 Protein - PDMH100027","description":"\u003cp\u003eRecombinant Human IL-29 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMH100027-20, PDMH100027-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL-29\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Interferon lambda-1; IFN-lambda-1; ytokine Zcyto21; Interleukin-29; IL29; IFNL1; ZCYTO21\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q8IU54\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Cardiovascular; Immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-10His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q8IU54\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK\/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Thr200\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4., 5% trehalose, 5% mannitol, 0.01% tween-80.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 22 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 28-35 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083610587315,"sku":"PDMH100027-20","price":264.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083610620083,"sku":"PDMH100027-100","price":418.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d8ec44aa-1ecf-45d8-b8ae-5c6058ed631d.png?v=1708945199","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-29-protein-pdmh100027","provider":"AFSBio Inc.","version":"1.0","type":"link"}