{"product_id":"recombinant-human-il-4-protein-rp00995","title":"Recombinant Human IL-4 Protein - RP00995","description":"\u003cp\u003eRecombinant Human IL-4 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00995-10, RP00995-20, RP00995-50, RP00995-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human IL-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His25-Ser153) of human IL-4 (Accession #NP_000580.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BCGF-1, BCGF1, BSF-1, BSF1, IL-4, IL4, BCGF1, BSF-1, BSF1, IL-4\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P05112-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3565\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.≥ 95 % as determined by HPLC.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 \/ IL-13 family. Interleukin-4 \/ IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 \/ IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and the maturation of T helper (Th) cells toward the Th2 phenotype.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured in a cell proliferation assay using TF 1 human erythroleukemic cells. The ED50 for this effect is 85-340 pg\/mL, corresponding to a specific activity of 2.94 × 10^6 ~1.17× 10^7 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198306902195,"sku":"RP00995-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198306934963,"sku":"RP00995-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198306967731,"sku":"RP00995-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198307000499,"sku":"RP00995-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_84bcdf4c-2b7c-44e6-b28d-c838f7ebc700.png?v=1766960410","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-4-protein-rp00995","provider":"AFSBio Inc.","version":"1.0","type":"link"}