{"product_id":"recombinant-human-il-4r-alpha-cd124-protein-rp00099","title":"Recombinant Human IL-4R alpha\/CD124 Protein - RP00099","description":"\u003cp\u003eRecombinant Human IL-4R alpha\/CD124 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00099-10, RP00099-20, RP00099-50, RP00099-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human IL-4R alpha\/CD124 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-His232) of human IL4R\/CD124 (Accession #NP_000409.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IL4R, CD124, IL-4RA, IL4RA\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P24394\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3566\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 85 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This protein is alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL4R at 2 μg\/mL (100 μL\/well) can bind recombinant human IL4. The ED50 of recombinant human IL4R is 2-4 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: GNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQH\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198295990451,"sku":"RP00099-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198296023219,"sku":"RP00099-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198296055987,"sku":"RP00099-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198296088755,"sku":"RP00099-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_c7819e1b-7bcc-446c-80c0-742b34a757ae.png?v=1766960262","url":"https:\/\/afsbio.com\/products\/recombinant-human-il-4r-alpha-cd124-protein-rp00099","provider":"AFSBio Inc.","version":"1.0","type":"link"}