{"product_id":"recombinant-human-il1f5-il36rn-protein-pksh031850","title":"Recombinant Human IL1F5\/IL36RN Protein - PKSH031850","description":"Recombinant Human IL1F5\/IL36RN Protein\n\nSizes: 20μg, 100μg\n\nCatalogue Numbers: PKSH031850-20, PKSH031850-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: IL1F5; IL36RN\n\nTarget Synonym: Interleukin-36 Receptor Antagonist Protein; FIL1 Delta; IL-1-Related Protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 Delta; IL-1 Delta; Interleukin-1 Family Member 5; IL-1F5; Interleukin-1 Receptor Antagonist Homolog 1; IL-1ra Homolog 1; Interleukin-1-Like Protein 1; IL-1L1; IL36RN; FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3\n\nUNIProt ID: Q9UBH0\n\nResearch Areas: immunology\n\nTarget Species: Human\n\nExpression Host: E.coli\n\nFusion Tag: None\n\nAccession: Q9UBH0\n\nBackground: Interleukin-1 family member 5 (IL-1F5); also known as interleukin 36 receptor antagonist (IL36RA); is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family; member 6 (IL1F6). IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A); beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1); which is present in epithelial barriers and takes part in local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor; single Ig IL-1R-related molecule (SIGIRR)\/TIR8; as the effects were not observed in SIGIRR− \/− mice. In contrast to its effects in brain tissue; IL-1F5 did not attenuate LPS-induced changes; or up-regulated IL-4 in macrophages or dendritic cells; suggesting that the effect is confined to the brain.\n\nSequence: Met 1-Asp155\n\nPurity: \u0026gt; 99 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: Please contact us for more information.\n\nCalculated MW: 17.1 kDa\n\nObserved MW: 18 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083648106675,"sku":"PKSH031850-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083648139443,"sku":"PKSH031850-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_cfe63c63-a9f2-4c84-bb1d-f55e93bf8f81.png?v=1708946148","url":"https:\/\/afsbio.com\/products\/recombinant-human-il1f5-il36rn-protein-pksh031850","provider":"AFSBio Inc.","version":"1.0","type":"link"}