{"product_id":"recombinant-human-il1rl1-st2-protein-fc-tagactive-pksh031875","title":"Recombinant Human IL1RL1\/ST2 Protein (Fc Tag)(Active) - PKSH031875","description":"Recombinant Human IL1RL1\/ST2 Protein (Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031875-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: IL1RL1; ST2\n\nTarget Symptom: DER4; FIT-1; IL1RL1; IL33R; IL-1 R4; ST2; ST2L; ST2V; T1\n\nResearch Area: Cardiovascular; immunology\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: ELISA\n\nFusion Tag: C-hFc\n\nAccession: NP_003847.2\n\nBackground: IL-1 receptor– like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.\n\nActivity: Immobilized human IL-33 at 10 μg\/ml (100 μl\/well) can bind human IL1RL1 \/ Fc Chimera with a linear range of 0.31-5 ng\/ml.\n\nSequence: Met 1-Phe 328\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 67.1 kDa\n\nObserved MW: 85-95 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104329236659,"sku":"PKSH031875-100","price":680.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_94b58ded-9730-4d0c-ac56-487b0d7523e2.png?v=1709294437","url":"https:\/\/afsbio.com\/products\/recombinant-human-il1rl1-st2-protein-fc-tagactive-pksh031875","provider":"AFSBio Inc.","version":"1.0","type":"link"}