{"product_id":"recombinant-human-il6st-cd130-protein-his-fc-tagactive-pksh031330","title":"Recombinant Human IL6ST\/CD130 Protein (His \u0026 Fc Tag)(Active) - PKSH031330","description":"\u003cp\u003eRecombinant Human IL6ST\/CD130 Protein (His \u0026amp; Fc Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH031330-20, PKSH031330-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IL6ST; CD130\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: CD130; CDW130; GP130; IL-6RB\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cell biology; Cardiovascular; Cancer; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His \u0026amp; Fc\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_002175.2\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130\/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130\/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130\/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130\/gp130 binds to IL6\/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130\/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.\u003c\/p\u003e\n\n\u003cp\u003eActivity: 1. Measured by its ability to bind human IL11Ra in a functional ELISA. \u003cbr\u003e\n2. Measured by its ability to inhibit the IL6 Rα enhancement of IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 0.2-0.8 μg\/ml in the presence I'n tho pesence of 50 nglml. rcombnant human LsR and 100 ng\/mL recombinant human IL-6.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Ile 618\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 96 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 125-140 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43114022797491,"sku":"PKSH031330-20","price":711.2,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43114022830259,"sku":"PKSH031330-100","price":1433.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_69aaaad9-07fb-43e9-a17a-002035cfec2b.png?v=1709550376","url":"https:\/\/afsbio.com\/products\/recombinant-human-il6st-cd130-protein-his-fc-tagactive-pksh031330","provider":"AFSBio Inc.","version":"1.0","type":"link"}