{"product_id":"recombinant-human-interleukin-13-variant-rhuil-13-variant-pr1061","title":"Recombinant Human Interleukin-13 Variant (rHuIL-13 variant) - PR1061","description":"\u003cp\u003eRecombinant Human Interleukin-13 Variant (rHuIL-13 variant)\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PR1061-2, PR1061-10\u003c\/p\u003e\n\n\u003cp\u003eSizes: 2µg, 10µg\u003c\/p\u003e\n\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: Approximately 12.5 kDa, a single non-glycosylated polypeptide chain containing 114 amino acids, with a substitution of Q for R at position 112 compared with the wild type IL-13.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;95% by SDS-PAGE and HPLC analyses.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of TF-1 cells was \u0026lt; 1.0 ng\/ml, corresponding to a specific activity of \u0026gt; 1×106 units\/mg. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL-13.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.2, containing 5% trehalose.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: SPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL TAGMYCAALE\u003cbr\u003e\n SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL\u003cbr\u003e\n LLHLKKLFRE GQFN\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Less than 1EU\/mg of rHuIL-13 variant as determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg\/ml. Stock solutions should be apportioned into working aliquots and stored at \u0026lt;-20°C. Further dilutions should be made in appropriate buffered solutions.\u003c\/p\u003e\n\n\u003cp\u003eStorage: This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze\/thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China\u003c\/p\u003e\n\n\u003cp\u003eDescription: The human IL-13 cDNA encodes a 132 amino acid protein containing a proposed 20 amino acid signal peptide. Human IL-13 shares approximately 30% amino acid sequence homology to human IL-4 and the two cytokines exhibit overlapping biological activities. Human IL-13 is produced by activated Th0, Th1-like Th2-like and CD8 T cells. Similarly to IL-4, IL-13 has multiple effects on the differentiation and functions of monocytes\/macrophages. IL-13 can suppress the cytotoxic functions of monocytes\/macrophages. It can also suppress the production of proinflammatory cytokines and upregulate the production of IL-1ra by monocytes\/macrophages.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"2µg","offer_id":42882218885299,"sku":"PR1061-2","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"10µg","offer_id":42882218918067,"sku":"PR1061-10","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_5f9d322d-4127-403b-b4c2-379b5510d8b4.jpg?v=1702049467","url":"https:\/\/afsbio.com\/products\/recombinant-human-interleukin-13-variant-rhuil-13-variant-pr1061","provider":"AFSBio Inc.","version":"1.0","type":"link"}