{"product_id":"recombinant-human-interleukin-2-rhuil-2-pr1065","title":"Recombinant Human Interleukin-2 (rHuIL-2) - PR1065","description":"\u003cp\u003eRecombinant Human Interleukin-2 (rHuIL-2)\u003c\/p\u003e\n\u003cp\u003eCatalogue Numbers: PR1065-10, PR1065-50, PR1065-1000\u003c\/p\u003e\n\u003cp\u003eSizes: 10µg, 50µg, 1.0mg \u003cspan data-mce-fragment=\"1\"\u003e(contact us for the 1.0mg option)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\u003cp\u003eMolecular Weight: Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids.\u003c\/p\u003e\n\u003cp\u003ePurity: \u0026gt;97% by SDS-PAGE and HPLC analyses.\u003c\/p\u003e\n\u003cp\u003eBiological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of murine CTLL-2 cells is less than 0.1 ng\/ml, corresponding to a specific activity of \u0026gt; 1 x 107 units\/mg.\u003c\/p\u003e\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\u003cp\u003eFormulation: Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.5.\u003c\/p\u003e\n\u003cp\u003eAA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLT\u003c\/p\u003e\n\u003cp\u003eEndotoxin: Less than 1EU\/g of rHuIL-2 as determined by LAL method.\u003c\/p\u003e\n\u003cp\u003eReconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg\/mL. Stock solutions should be apportioned into working aliquots and stored at \u0026lt;-20C. Further dilutions should be made in appropriate buffered solutions.\u003c\/p\u003e\n\u003cp\u003eStorage: This lyophilized preparation is stable at 2-8C, but should be kept at -20C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze\/thaw cycles.\u003c\/p\u003e\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China\u003c\/p\u003e\n\u003cp\u003eDescription: Interleukin 2 is a protein that has a variety of immunologic functions, the most notable being the ability of IL-2 to promote the proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows an approximately 60% sequence similarity, and human sequence IL-2 has been found to be active on murine cell lines. Some of the biological activities attributed to IL-2 include:\u003cbr\u003e ● induction of secretion of interferon-γ and tumor necrosis factors -α and -β from peripheral blood mononuclear cells\u003cbr\u003e ● stimulation of the rate of synthesis of c-myc RNA and transferrin receptor\u003cbr\u003e ● activation of neutrophils\u003cbr\u003e ● stimulation of proliferation and maturation of activated helper T cells\u003cbr\u003e ● stimulation of proliferation of activated and natural killer cells and tumor-infiltrating lymphocytes, as well as enhancement of the ability of these cytotoxic lymphocytes to kill target cells\u003cbr\u003e ● induction of the expression of IL-2 receptors on T cells\u003cbr\u003e ● stimulation of proliferation of antibody-producing B cells\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"10µg","offer_id":42880313131187,"sku":"PR1065-10","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"50µg","offer_id":42880313163955,"sku":"PR1065-50","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_fc7f10b9-a550-43a9-b871-9df8b091aeac.jpg?v=1701973220","url":"https:\/\/afsbio.com\/products\/recombinant-human-interleukin-2-rhuil-2-pr1065","provider":"AFSBio Inc.","version":"1.0","type":"link"}