{"product_id":"recombinant-human-interleukin-23-il-23-c-6his-pksh033877","title":"Recombinant Human Interleukin-23\/IL-23 (C-6His) - PKSH033877","description":"\u003cp\u003eRecombinant Human Interleukin-23\/IL-23 (C-6His)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033877-10, PKSH033877-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Interleukin-23; IL-23\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Microbiology; Cancer; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: Cell culture\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9NPF7\u0026amp;P29460\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9NPF7\u0026amp;P29460\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its ability to induce STAT reporter activity in 293F human embryonic kidney cells. The ED50 for this effect is 70-210 ng\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Arg20-Pro189\u0026amp;Ile23-Ser328\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 19.7\u0026amp;34.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 19-21\u0026amp;40-60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118164082867,"sku":"PKSH033877-10","price":387.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118164115635,"sku":"PKSH033877-50","price":1138.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_49c1e949-e302-44c0-abd5-5fc053857cac.png?v=1709637359","url":"https:\/\/afsbio.com\/products\/recombinant-human-interleukin-23-il-23-c-6his-pksh033877","provider":"AFSBio Inc.","version":"1.0","type":"link"}