{"product_id":"recombinant-human-interleukin-31-rhu-il-31-pr1070","title":"Recombinant Human Interleukin-31 (rHu IL-31) - PR1070","description":"\u003cp\u003eRecombinant Human Interleukin-31 (rHu IL-31)\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PR1070-2, PR1070-10\u003c\/p\u003e\n\n\u003cp\u003eSizes: 2µg, 10µg\u003c\/p\u003e\n\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: Approximately 15.8 kDa, a single non-glycosylated polypeptide chain containing 141 amino acids.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;97% by SDS-PAGE and HPLC analyses.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: Fully biologically active when compared to standard.Measured by its ability to induce STAT3 activation in U-87 MG human glioblastoma\/astrocytoma cells. 5 ng\/mL of rhIL31 can effectively induce STAT3 activation.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2mm filtered concentrated solution in PBS.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Less than 1EU\/mg of rHuIL-31 as determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg\/mL. Stock solutions should be apportioned into working aliquots and stored at \u0026lt;-20°C. Further dilutions should be made in appropriate buffered solutions.\u003c\/p\u003e\n\n\u003cp\u003eStorage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze\/thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China\u003c\/p\u003e\n\n\u003cp\u003eDescription: Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL\/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"2µg","offer_id":42882219311283,"sku":"PR1070-2","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"10µg","offer_id":42882219344051,"sku":"PR1070-10","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_99bfb679-4eee-4e16-8579-a21d3b1e8743.jpg?v=1702049479","url":"https:\/\/afsbio.com\/products\/recombinant-human-interleukin-31-rhu-il-31-pr1070","provider":"AFSBio Inc.","version":"1.0","type":"link"}