{"product_id":"recombinant-human-jam-a-f11r-protein-fc-tagactive-pksh031772","title":"Recombinant Human JAM-A\/F11R Protein (Fc Tag)(Active) - PKSH031772","description":"Recombinant Human JAM-A\/F11R Protein (Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031772-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: JAM-A; F11R\n\nTarget Symptom: Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM; JAMA; JCAM; KAT\n\nResearch Area: Signal Transduction; Cardiovascular; \n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Cell culture; ELISA\n\nFusion Tag: C-hFc\n\nAccession: NP_058642.1\n\nBackground: Junctional adhesion molecule-A (JAM-A); also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321); is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells; as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1; involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily; JAM-A protein involves in platelet adhesion; secretion and aggregation; and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition; it may be a potential therapeutic target for breast cancer.\n\nActivity: Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When 8 x 10\u003csup\u003e4\u003c\/sup\u003ecells\/well are added to JAM-A-Fc coated plates (2. 5μg\/mL, 100 μL\/well)in the presence of 20 ng\/mL PMA, approximately 30-40% will adhere after 30 minutes at 37℃.\n\nSequence: Met 1-Ala 242\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 50 kDa\n\nObserved MW: 61 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104325533875,"sku":"PKSH031772-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_83fe16e7-accf-48f8-a9c1-601c2926441f.png?v=1709294348","url":"https:\/\/afsbio.com\/products\/recombinant-human-jam-a-f11r-protein-fc-tagactive-pksh031772","provider":"AFSBio Inc.","version":"1.0","type":"link"}