{"product_id":"recombinant-human-kallikrein-11-klk11-protein-rp00149","title":"Recombinant Human Kallikrein-11\/KLK11 Protein - RP00149","description":"\u003cp\u003eRecombinant Human Kallikrein-11\/KLK11 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00149-10, RP00149-20, RP00149-50, RP00149-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Kallikrein-11\/KLK11 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Asn250) of human KLK11\/Kallikrein-11 (Accession #NP_006844.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: KLK11, PRSS20, TLSP\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9UBX7\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 11012\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: kallikrein-related peptidase 11 (KLK11), also known as hippostasin, trypsin-like serine protease and PRSS20, is a member of human tissue kallikrein family. It is a subgroup of serine proteases with diverse physiological functions, which is implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.The KLK11 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.Two alternatively spliced forms exist, resulting in 250 (isoform 1) and 282 (isoform 2) amino acid sequences,respectively. Isoform 1 is predominantly expressed in brain whereas isoform 2 is preferentially expressed in prostate. KLK11 is a novel marker for ovarian and prostate cancer carcinomas. Recombinant human KLK11, after being activated by thermolysin, is active against a thioester substrate. This activity can be inhibited by AEBSF dichloroisocoumarin, and aprotinin.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Lys-ThioBenzyl ester (Z-Lys-SBzl), in the presence of 5,5’Dithio-bis (2-nitrobenzoic acid) (DTNB). The specific activity is \u0026gt;141.40 pmol\/min\/μg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of 20mM Tris,150mM NaCl, pH 8.0.Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: MRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNN\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198302183603,"sku":"RP00149-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198302216371,"sku":"RP00149-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198302249139,"sku":"RP00149-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198302281907,"sku":"RP00149-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_0ef5bcd4-3411-40f9-90c0-6f27a5ff3d4a.png?v=1766960342","url":"https:\/\/afsbio.com\/products\/recombinant-human-kallikrein-11-klk11-protein-rp00149","provider":"AFSBio Inc.","version":"1.0","type":"link"}