{"product_id":"recombinant-human-lair-1-cd305-protein-rp01439","title":"Recombinant Human LAIR-1\/CD305 Protein - RP01439","description":"\u003cp\u003eRecombinant Human LAIR-1\/CD305 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01439-10, RP01439-20, RP01439-50, RP01439-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human LAIR-1\/CD305 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-His163) of human LAIR1\/CD305 (Accession #NP_068352.2) fused with a 6×His, Avi tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LAIR1, CD305, LAIR-1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q6GTX8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3903\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to \"effector\" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u0026amp;Avi\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERESRSTYNDTEDVSQASPSESEARFRIDSVSEGNAGPYRCIYYKPPKWSEQSDYLELLVKETSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEH\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198260699315,"sku":"RP01439-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198260732083,"sku":"RP01439-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198260764851,"sku":"RP01439-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198260797619,"sku":"RP01439-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f8c1bdca-a0ef-4b98-a79d-c6827dd311f9.png?v=1766959846","url":"https:\/\/afsbio.com\/products\/recombinant-human-lair-1-cd305-protein-rp01439","provider":"AFSBio Inc.","version":"1.0","type":"link"}