{"product_id":"recombinant-human-lair-2-cd306-protein-rp01034","title":"Recombinant Human LAIR-2\/CD306 Protein - RP01034","description":"\u003cp\u003eRecombinant Human LAIR-2\/CD306 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01034-10, RP01034-20, RP01034-50, RP01034-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human LAIR-2\/CD306 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-Pro152) of human LAIR2 (Accession #NP_002279) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LAIR2, CD306\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q6ISS4\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3904\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD36, is a 131 amino acid protein containing one lg-like C2-type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% aa identity across the signal sequence and extracellular domains, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. LAIR2 is thought to be secreted and may help modulate mucosal tolerance.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: Measured by the ability of the immobilized protein to support the adhesion of HT-29 human colon adenocarcinoma cells. When 5 x 104 cells\/well are added to rhLAIR-2 coated plates (50 μg\/mL with 100 μL\/well), approximately 50%-60% will adhere after 10 minutes at 37℃.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAP\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198315225267,"sku":"RP01034-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198315258035,"sku":"RP01034-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198315290803,"sku":"RP01034-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198315323571,"sku":"RP01034-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_47aa7239-93fc-4816-9eb0-6b2c7d67155f.png?v=1766960508","url":"https:\/\/afsbio.com\/products\/recombinant-human-lair-2-cd306-protein-rp01034","provider":"AFSBio Inc.","version":"1.0","type":"link"}