{"product_id":"recombinant-human-lair1-protein-fc-tag-pksh030465","title":"Recombinant Human LAIR1 Protein (Fc Tag) - PKSH030465","description":"Recombinant Human LAIR1 Protein (Fc Tag)\n\nSize: 50μg\n\nCatalogue Number: PKSH030465-50\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: LAIR1\n\nTarget Symptom: Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305; LAIR1\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nFusion Tag: C-hFc\n\nAccession: Q6GTX8.1\n\nBackground: Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to \" effector\" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.\n\nSequence: Met 1-Tyr165\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4 \nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 42.8 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107267379379,"sku":"PKSH030465-50","price":635.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5c62503d-4a56-4231-b154-b7a09eeb6cf6.png?v=1709382214","url":"https:\/\/afsbio.com\/products\/recombinant-human-lair1-protein-fc-tag-pksh030465","provider":"AFSBio Inc.","version":"1.0","type":"link"}