{"product_id":"recombinant-human-ldlr-protein-his-tag-avi-pksh032711","title":"Recombinant Human LDLR Protein (His Tag\/AVI) - PKSH032711","description":"\u003cp\u003eRecombinant Human LDLR Protein (His Tag\/AVI)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032711-20, PKSH032711-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: LDLR\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Low-Density Lipoprotein Receptor; LDL Receptor; LDLR; FH; FHC; LDL R; LDL Receptor; LDLCQ2\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P01130\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cardiovascular; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eConjugation: Biotinylated\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His-AVI\u003c\/p\u003e\n\n\u003cp\u003eAccession: P01130\u003c\/p\u003e\n\n\u003cp\u003eBackground: Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala22-Arg788\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 90.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 137 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43068881862835,"sku":"PKSH032711-20","price":596.3,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43068881895603,"sku":"PKSH032711-100","price":1610.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_96d18269-c12b-4ce4-8a59-ab405cc568b5.png?v=1708598501","url":"https:\/\/afsbio.com\/products\/recombinant-human-ldlr-protein-his-tag-avi-pksh032711","provider":"AFSBio Inc.","version":"1.0","type":"link"}