{"product_id":"recombinant-human-lgr5-gpr49-protein-rp00730","title":"Recombinant Human LGR5 \/ GPR49 protein - RP00730","description":"\u003cp\u003eRecombinant Human LGR5 \/ GPR49 protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00730-10, RP00730-20, RP00730-50, RP00730-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human LGR5 \/ GPR49 protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly 22 - Arg 561) of Human LGR5 \/ GPR49(Accession #NM_003667.3) fused with His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LGR5, GPR49, GPR67, Leucine-rich repeat-containing G-protein coupled receptor 5\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O75473-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8549\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt\/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5\/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: GSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198241988787,"sku":"RP00730-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198242021555,"sku":"RP00730-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198242054323,"sku":"RP00730-50","price":315.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198242087091,"sku":"RP00730-100","price":504.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_44c4bfc8-2ed4-44fc-a9c2-892ebff712a9.png?v=1766959627","url":"https:\/\/afsbio.com\/products\/recombinant-human-lgr5-gpr49-protein-rp00730","provider":"AFSBio Inc.","version":"1.0","type":"link"}