{"product_id":"recombinant-human-lmcd1-dyxin-protein-his-tag-pksh032706","title":"Recombinant Human LMCD1\/Dyxin Protein (His Tag) - PKSH032706","description":"\u003cp\u003eRecombinant Human LMCD1\/Dyxin Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032706-10, PKSH032706-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: LMCD1; Dyxin\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: LIM and cysteine-rich domains protein 1; LMCD1; Dyxin\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9NZU5\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Neuroscience;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His \u0026amp; C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9NZU5\u003c\/p\u003e\n\n\u003cp\u003eBackground: LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin\/nuclear factor of activated T-cells signaling pathway.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Ser365\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44.0 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 45 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068881076403,"sku":"PKSH032706-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068881109171,"sku":"PKSH032706-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b24cae8c-25b4-45b3-afda-a896429efc61.png?v=1708598489","url":"https:\/\/afsbio.com\/products\/recombinant-human-lmcd1-dyxin-protein-his-tag-pksh032706","provider":"AFSBio Inc.","version":"1.0","type":"link"}