{"product_id":"recombinant-human-man1b1-protein-his-tag-pksh032400","title":"Recombinant Human MAN1B1 Protein (His Tag) - PKSH032400","description":"\u003cp\u003eRecombinant Human MAN1B1 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032400-10, PKSH032400-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MAN1B1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1; 2-Alpha-Mannosidase; ER Alpha-1; 2-Mannosidase; ER Mannosidase 1; ERMan1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; Mannosidase Alpha Class 1B Member 1; MAN1B1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9UKM7\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Tags \u0026amp; Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9UKM7\u003c\/p\u003e\n\n\u003cp\u003eBackground: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Asp106-Ala699\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 10mM reduced Glutathione, pH 8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 68.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 68 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43092774518963,"sku":"PKSH032400-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43092774551731,"sku":"PKSH032400-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a3c7c9a4-1efc-4df0-b6a0-9a6a7215b9b8.png?v=1709119714","url":"https:\/\/afsbio.com\/products\/recombinant-human-man1b1-protein-his-tag-pksh032400","provider":"AFSBio Inc.","version":"1.0","type":"link"}