{"product_id":"recombinant-human-mature-bmp-7-protein-rp02513s","title":"Recombinant Human Mature BMP-7 Protein - RP02513S","description":"\u003cp\u003eRecombinant Human Mature BMP-7 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP02513S-10, RP02513S-20, RP02513S-50, RP02513S-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human BMP-7 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser293-His431) of Human BMP-7(Accession #NP_001710.1) fused with No Tag.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BMP7, OP1, Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, Eptotermin alfa\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P18075\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 655\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BMP-7 (Bone morphogenetic protein 7) is a bone morphogenetic protein which belongs to the TGF-β superfamily. OP-1 is expressed in the brain, kidneys, and bladder. BMP-7 may be involved in bone homeostasis and plays a key role in the transformation of mesenchymal cells into bone and cartilage. The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes. BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types. Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma. It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed. It is found that BMP7 has the potential for treatment of chronic kidney disease.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.The ED50 for this effect is 34.9-139.58 ng\/mL, corresponding to a specific activity of 7.2×10^3 ~2.87×10^4 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: No-Tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of 50mM acetic acid, pH3.6.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: STGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198342553779,"sku":"RP02513S-10","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198342586547,"sku":"RP02513S-20","price":392.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198342619315,"sku":"RP02513S-50","price":630.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198342652083,"sku":"RP02513S-100","price":1008.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_6233579a-a557-4c2f-b19c-d2cfee1e462b.png?v=1766960821","url":"https:\/\/afsbio.com\/products\/recombinant-human-mature-bmp-7-protein-rp02513s","provider":"AFSBio Inc.","version":"1.0","type":"link"}