MT1 Melatonin receptors 1 are powerful therapeutic candidates for insomnia, circadian sleep disorders, depression, cardiovascular regulation, cancer, and neurodegenerative diseases.
CALIXAR’s MT1 (Melatonin receptor 1) helps you identify, develop, and test new molecules and therapeutic antibodies for CNS neuroprotection treatments for insomnia, circadian sleep disorders, depression, cardiovascular regulation, cancer, and neurodegenerative diseases.
CALIXAR's Melatonin receptor 1 (MT1) is a class A GPCR that modulates neuronal firing, arterial vasoconstriction, cell proliferation in cancer cells, and reproductive and metabolic functions.
Target name: Melatonin receptor type 1A (MT1)
Catalogue number: PP2
Class: GPCR Class A
Sequence: Full-length, wildtype sequence, with a N-terminus Strep tag II, 8xHis-tag, and TEV protease cleavage site.
Affinity Tag: Strepx2/His (both N-terminal)
Origin: Human (Homo sapiens)
Theor. MW: 44,8kDa
Accession #: P48039 (UniProt)
Shipment temperature: Dry Ice
Storage conditions: Store at -80°C
Expression system: Sf9 insect cells (baculovirus)
Purification: Metal Affinity Chromatography in presence of Sarkosyl/CHS
Activity: Confirmed by radiobinding assay and activation of Gi
Concentration: Up to 5mg/ml
Sample buffer: 25mM Na2HPO4 pH 8.0, 150mM NaCl, 0.86%/0.18% Sarkosyl/CHS
Available quantity: From 10µg up to mg scale