{"product_id":"recombinant-human-metap1-protein-pksh033589","title":"Recombinant Human METAP1 Protein - PKSH033589","description":"\u003cp\u003eRecombinant Human METAP1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033589-10, PKSH033589-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: METAP1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Methionine aminopeptidase 1; MAP 1; MetAP 1; Peptidase M 1; METAP1; MAP1A; MetAP1A\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: None\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P53582\u003c\/p\u003e\n\n\u003cp\u003eAccession: P53582\u003c\/p\u003e\n\n\u003cp\u003eBackground: Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)\/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Phe386\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10%glycerol, pH8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 43.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 38\u0026amp;45-50 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113973448883,"sku":"PKSH033589-10","price":368.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113973481651,"sku":"PKSH033589-50","price":625.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_99d22202-2392-436c-973c-6a60fd04c520.png?v=1709549430","url":"https:\/\/afsbio.com\/products\/recombinant-human-metap1-protein-pksh033589","provider":"AFSBio Inc.","version":"1.0","type":"link"}