{"product_id":"recombinant-human-micb-protein-his-tagactive-pdmh100004","title":"Recombinant Human MICB Protein (His Tag)(Active) - PDMH100004","description":"Recombinant Human MICB Protein (His Tag)(Active)\n\nSizes: 20μg, 100μg\n\nCatalogue Numbers: PDMH100004-20, PDMH100004-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: MICB\n\nTarget Symptom: PERB11.2\n\nResearch Area: immunology\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: ELISA\n\nFusion Tag: C-His\n\nUNIProt ID: Q29980\n\nAccession: Q29980\n\nBackground: MHC class I polypeptide-related sequence B; also known as MICB; is a heavily glycosylated protein serving as a ligand for the type I  I receptor NKG2D. MICB shares 85% amino acid identity with MICA; a closely related protein; both of which contain three extracellular immunoglobulin-like domains; but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen; binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells; CD8+αβ T cells; and γδ T cells on which the receptor is expressed. MICA\/B are minimally expressed on normal cells; but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA\/B recognition thus is involved in tumor surveillance; viral infections; and autoimmune diseases.\n\nActivity: Immobilized human MICB-His at 10 μg\/ml (100 μl\/well) can bind human NKG2D, The EC50 of human NKG2D is 0.52-1. 2 μg\/ml.\n\nSequence: Met 1-Gly 298\n\nPurity: \u0026gt; 98 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4.\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 33 kDa\n\nObserved MW: 45-50 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118132199603,"sku":"PDMH100004-20","price":264.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118132232371,"sku":"PDMH100004-100","price":418.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_2905fa2a-2838-4252-a001-30956a6f5dba.png?v=1709636804","url":"https:\/\/afsbio.com\/products\/recombinant-human-micb-protein-his-tagactive-pdmh100004","provider":"AFSBio Inc.","version":"1.0","type":"link"}