{"product_id":"recombinant-human-mitf-protein-rp01520","title":"Recombinant Human MITF Protein - RP01520","description":"\u003cp\u003eRecombinant Human MITF Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01520-10, RP01520-20, RP01520-50, RP01520-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human MITF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His402-Cys526) of human MITF (Accession #NP_000239.1) fused with a raFc tag at the N-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CMM8, COMMAD, MI, WS2, WS2A, bHLHe32, MITF, COMMAD, MI, WS2, WS2A, bHLHe32\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O75030\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4286\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Microphthalmia-associated transcription factor (MITF) is a member of the basic helix-loop-helix leucine zipper (bHLH-Zip) family and functions as the master regulator of the melanocytic lineage.MITF (Microphthalmia-associated transcription factor) is a lineage-specific transcription factor that plays a critical role in melanocyte homeostasis and whose deregulation has been shown to contribute to melanoma disease. Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Microphthalmia-associated transcription factor (MITF) regulates the transcription of its target genes by binding to their promoters. Microphthalmia-associated transcription factor (MITF) is a key regulator of differentiation of melanocytes and retinal pigment epithelial cells, but it also has functions in non-pigment cells.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: N-Rabbit Fc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: HGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198253097139,"sku":"RP01520-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198253129907,"sku":"RP01520-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198253162675,"sku":"RP01520-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198253195443,"sku":"RP01520-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_28005591-19c6-46b3-8b81-b8c19b4007b7.png?v=1766959762","url":"https:\/\/afsbio.com\/products\/recombinant-human-mitf-protein-rp01520","provider":"AFSBio Inc.","version":"1.0","type":"link"}