{"product_id":"recombinant-human-mkk6-protein-207-ser-asp-211-thr-asp-his-gst-tagactive-pksh030414","title":"Recombinant Human MKK6 Protein (207 Ser\/Asp, 211 Thr\/Asp, His \u0026 GST Tag)(Active) - PKSH030414","description":"\u003cp\u003eRecombinant Human MKK6 Protein (207 Ser\/Asp, 211 Thr\/Asp, His \u0026amp; GST Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030414-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MKK6\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3; MAP2K6\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: Baculovirus-Insect Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: Enzyme\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His \u0026amp; GST\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P52564\u003c\/p\u003e\n\n\u003cp\u003eAccession: P52564-1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK \/ ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the protein kinase superfamily; STE Ser \/ Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 \/ MKK6 contains one protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors; cytokines; ultraviolet light; and stress-inducing agents. MAP2K6 \/ MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 \/ MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 \/ MKK6 is expressed in skeletal muscle; heart; and in lesser extent in liver or pancreas.\u003c\/p\u003e\n\n\u003cp\u003eActivity: The specific activity was determined to be 1250 nmol\/min\/mg using inactive MAPK14 as substrate.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Asp 334; Ser 207\/Asp; Thr 211\/Asp\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 88 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 65.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104349487283,"sku":"PKSH030414-50","price":1003.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b02e70bb-0639-4778-a37d-8e2bd44ca043.png?v=1709294923","url":"https:\/\/afsbio.com\/products\/recombinant-human-mkk6-protein-207-ser-asp-211-thr-asp-his-gst-tagactive-pksh030414","provider":"AFSBio Inc.","version":"1.0","type":"link"}