{"product_id":"recombinant-human-mkk6-protein-his-gst-tag-pksh030415","title":"Recombinant Human MKK6 Protein (His \u0026 GST Tag) - PKSH030415","description":"\u003cp\u003eRecombinant Human MKK6 Protein (His \u0026amp; GST Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030415-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MKK6\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, MAP2K6\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P52564\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: Baculovirus-Insect Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His \u0026amp; GST\u003c\/p\u003e\n\n\u003cp\u003eAccession: P52564-1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK \/ ERK kinase 6, SAPKK3, MAP2K6 and MKK6, is a protein which belongs to the protein kinase superfamily, STE Ser \/ Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 \/ MKK6 contains one protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors, cytokines, ultraviolet light, and stress-inducing agents. MAP2K6 \/ MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 \/ MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 \/ MKK6 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Asp 334\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 80 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 8.0\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 65.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43155063603379,"sku":"PKSH030415-50","price":1003.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_297a2ce6-982d-4780-b9fb-801daef90aa8.png?v=1710438254","url":"https:\/\/afsbio.com\/products\/recombinant-human-mkk6-protein-his-gst-tag-pksh030415","provider":"AFSBio Inc.","version":"1.0","type":"link"}