{"product_id":"recombinant-human-mouse-rat-bdnf-protein-active-pksh033808","title":"Recombinant Human\/Mouse\/Rat BDNF Protein (Active) - PKSH033808","description":"\u003cp\u003eRecombinant Human\/Mouse\/Rat BDNF Protein (Active)\u003c\/p\u003e\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\u003cp\u003eCatalogue Numbers: PKSH033808-20, PKSH033808-100\u003c\/p\u003e\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\u003cp\u003eAbbreviation: BDNF\u003c\/p\u003e\n\u003cp\u003eTarget Symptom: Brain-Derived Neurotrophic Factor; BDNF; Abrineurin\u003c\/p\u003e\n\u003cp\u003eResearch Area: Cardiovascular; Neuroscience; metabolism\u003c\/p\u003e\n\u003cp\u003eTarget Species: Human\/Mouse\/Rat Expression\u003c\/p\u003e\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\u003cp\u003eApplication: Cell culture \u003c\/p\u003e\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\u003cp\u003eUNIProt ID: P23560\u003c\/p\u003e\n\u003cp\u003eAccession: P23560\u003c\/p\u003e\n\u003cp\u003eBackground: Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF; NT-3 and NT-4; BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor; also known as p75). BDNF promotes the survival; growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson' s and Alzheimer' s disease.\u003c\/p\u003e\n\u003cp\u003eActivity: Measure by its ability to induce proliferation in BaF3 cells transfected with TrkB. The ED50 for this effect is \u0026lt; 2 ng\/mL. \u003c\/p\u003e\n\u003cp\u003eSequence: His129-Arg247\u003c\/p\u003e\n\u003cp\u003ePurity: \u0026gt; 98 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM sodium citrate, 0.2M NaCl, pH 3.5 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\u003cp\u003eCalculated MW: 13 kDa\u003c\/p\u003e\n\u003cp\u003eObserved MW: 14 kDa\u003c\/p\u003e\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118160249011,"sku":"PKSH033808-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118160281779,"sku":"PKSH033808-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_72b851b3-4bca-44a7-a79f-4e2a4f588880.png?v=1709637315","url":"https:\/\/afsbio.com\/products\/recombinant-human-mouse-rat-bdnf-protein-active-pksh033808","provider":"AFSBio Inc.","version":"1.0","type":"link"}