{"product_id":"recombinant-human-mouse-rat-mature-tgf-beta-3-protein-rp00645","title":"Recombinant Human\/Mouse\/Rat mature TGF-beta 3 Protein - RP00645","description":"\u003cp\u003eRecombinant Human\/Mouse\/Rat mature TGF-beta 3 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00645-10, RP00645-20, RP00645-50, RP00645-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human\/Mouse\/Rat TGF-beta 3 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Ala301-Ser412(Tyr340Phe)) of human TGF-beta 3\/TGFB3 (Accession #P10600).\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TGFB3, ARVD, ARVD1, LDS5, RNHF, TGF-beta3\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P10600\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7043\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Transforming growth factor beta 3(TGFB3) is a member of a TGF - β superfamily which is defined bytheirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form ofTGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subsetofintegrins. It binds with high affinity to TGF- β RII, a type II serine\/threonine kinase receptor. TGFB3 is involvedincell differentiation, embryogenesis and development.It is believed to regulate molecules involved incellularadhesion and extracellular matrix (ECM) formation during the process of palate development. WithoutTGF-β3,mammals develop a deformity known as a cleft palate.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 24.2-96.6 pg\/mL, corresponding to a specific activity of 1.04×10^7~4.17×10^7 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYFANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198306115763,"sku":"RP00645-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198306148531,"sku":"RP00645-20","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198306181299,"sku":"RP00645-50","price":490.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198306214067,"sku":"RP00645-100","price":784.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_b8f38e67-cd23-463d-8da2-a7e43ac65f54.png?v=1766960397","url":"https:\/\/afsbio.com\/products\/recombinant-human-mouse-rat-mature-tgf-beta-3-protein-rp00645","provider":"AFSBio Inc.","version":"1.0","type":"link"}