{"product_id":"recombinant-human-msr1-cd204-protein-rp01033","title":"Recombinant Human MSR1\/CD204 Protein - RP01033","description":"\u003cp\u003eRecombinant Human MSR1\/CD204 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01033-10, RP01033-20, RP01033-50, RP01033-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human MSR1\/CD204 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys77-Leu451) of human CD204 (Accession #NP_619729.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2, MSR1, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P21757\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4481\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This protein is the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA.Immobilized Human MSR1 Protein at 1μg\/mL (100 μL\/well) can bind MSR1 Rabbit pAb with a linear range of 0.76-2.88 ng\/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human A-I\/APOA1 at 5μg\/mL (100 μL\/well) can bind Human MSR1\/CD204 with a linear range of 1-49.4ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: KWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198312702131,"sku":"RP01033-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198312734899,"sku":"RP01033-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198312767667,"sku":"RP01033-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198312800435,"sku":"RP01033-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_8a80427e-6b88-47fc-a568-e8ddf17c3be6.png?v=1766960476","url":"https:\/\/afsbio.com\/products\/recombinant-human-msr1-cd204-protein-rp01033","provider":"AFSBio Inc.","version":"1.0","type":"link"}