{"product_id":"recombinant-human-n-glycosylase-ogg1-protein-gst-tag-pksh032809","title":"Recombinant Human N-Glycosylase\/OGG1 Protein (GST Tag) - PKSH032809","description":"\u003cp\u003eRecombinant Human N-Glycosylase\/OGG1 Protein (GST Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032809-10, PKSH032809-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: N-Glycosylase; OGG1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: N-Glycosylase\/DNA Lyase; 8-Oxoguanine DNA Glycosylase; DNA-(Apurinic or Apyrimidinic Site) Lyase; AP Lyase; OGG1; MMH; MUTM; OGH1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O15527\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; epigenetics and nuclear signal\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-GST\u003c\/p\u003e\n\n\u003cp\u003eAccession: O15527\u003c\/p\u003e\n\n\u003cp\u003eBackground: Human N-Glycosylase\/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7, 8-dihydro-8-oxoguanine and 2, 6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Gly345\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 65.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 66 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068733980851,"sku":"PKSH032809-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068734013619,"sku":"PKSH032809-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_174b9516-0e7b-4ced-bff1-3d38c158c124.png?v=1708597223","url":"https:\/\/afsbio.com\/products\/recombinant-human-n-glycosylase-ogg1-protein-gst-tag-pksh032809","provider":"AFSBio Inc.","version":"1.0","type":"link"}