{"product_id":"recombinant-human-orp150-hsp12a-protein-his-tag-pksh032553","title":"Recombinant Human ORP150\/HSP12A Protein (His Tag) - PKSH032553","description":"\u003cp\u003eRecombinant Human ORP150\/HSP12A Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032553-10, PKSH032553-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ORP150; HSP12A\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170; HYOU1; ORP150; Grp170; HSP12A\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9Y4L1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cardiovascular; Neuroscience; Cancer; epigenetics and nuclear signal; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-10His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9Y4L1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Hypoxia up-regulated protein 1(HYOU1) is a member of the heat shock protein 70 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1, HSPC1(HSP86), HSPA5(Bip), HSPD1(HSP60), and several isoforms of the two testis-specific HSP70 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in many tissues, such as liver, pancreas, macrophages within aortic atherosclerotic plaques, and in breast cancers. HYOU1 has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. It may play a role as a molecular chaperone and participate in protein folding. Suppression of HYOU1 is associated with accelerated apoptosis. It is suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor in vasiveness.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met695-Leu999\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 36 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 65-75 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068851945651,"sku":"PKSH032553-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068851978419,"sku":"PKSH032553-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f7e71713-5e11-4dc2-8046-86d6ed3bedb5.png?v=1708598210","url":"https:\/\/afsbio.com\/products\/recombinant-human-orp150-hsp12a-protein-his-tag-pksh032553","provider":"AFSBio Inc.","version":"1.0","type":"link"}