{"product_id":"recombinant-human-ox40-tnfrsf4-protein-fc-tagactive-pksh032843","title":"Recombinant Human OX40\/TNFRSF4 Protein (Fc Tag)(Active) - PKSH032843","description":"\u003cp\u003eRecombinant Human OX40\/TNFRSF4 Protein (Fc Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032843-10, PKSH032843-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: OX40; TNFRSF4\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Recombinant Human OX40\/TNFRSF4 Protein (C-Fc)\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: immunology; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P43489\u003c\/p\u003e\n\n\u003cp\u003eAccession: P43489\u003c\/p\u003e\n\n\u003cp\u003eBackground: OX40; also termed CD134 and TNFRSF4; is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions; including cytokine production; expansion; and survival; are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance; peripheral T-cell homeostasis; and T-cell-mediated inflammatory diseases.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human OX40L-6His(Cat: PKSH032842) at 2μg\/ml(100 μl\/well) can bind Human OX40-Fc. The ED50 of Human OX40-Fc is 4. 23 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu29-Ala216\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 46.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 70 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118149337267,"sku":"PKSH032843-10","price":163.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118149370035,"sku":"PKSH032843-50","price":474.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5a45bde6-9a9e-4c04-972c-6e0b25c74c8e.png?v=1709637119","url":"https:\/\/afsbio.com\/products\/recombinant-human-ox40-tnfrsf4-protein-fc-tagactive-pksh032843","provider":"AFSBio Inc.","version":"1.0","type":"link"}