{"product_id":"recombinant-human-ox40-tnfrsf4-protein-his-tagactive-pksh033416","title":"Recombinant Human OX40\/TNFRSF4 Protein (His Tag)(Active) - PKSH033416","description":"\u003cp\u003eRecombinant Human OX40\/TNFRSF4 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033416-10, PKSH033416-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: OX40; TNFRSF4\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Tumor necrosis factor receptor superfamily member 4; TNFRSF4; OX40; CD134; Txgp1; ACT35; IMD16; TXGP1L\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: immunology; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_003318.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human OX40L-His(Cat: PKSH032842) at 0.1μg\/ml(100 μl\/well) can bind Biotinylated Human OX40-His. The ED50 of Human OX40-His is 14.89 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu29-Ala216\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 21.0 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 35-40 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43114025353395,"sku":"PKSH033416-10","price":163.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43114025418931,"sku":"PKSH033416-50","price":474.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_aec70708-51d7-44ed-bec3-a3b05d0c577e.png?v=1709550420","url":"https:\/\/afsbio.com\/products\/recombinant-human-ox40-tnfrsf4-protein-his-tagactive-pksh033416","provider":"AFSBio Inc.","version":"1.0","type":"link"}