{"product_id":"recombinant-human-p-glycoprotein1-abcb1-protein-his-tag-pdeh100361","title":"Recombinant Human P-glycoprotein1\/ABCB1 protein (His tag) - PDEH100361","description":"\u003cp\u003eRecombinant Human P-glycoprotein1\/ABCB1 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEH100361-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: P-glycoprotein1; ABCB1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ATP-dependent translocase ABCB1; ABCB1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD243;\u003c\/p\u003e \n\n\u003cp\u003eUNIProt ID: P08183\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Neuroscience; \u003cbr\u003e\nsignal Transduction; stem Cells; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P08183\u003c\/p\u003e\n\n\u003cp\u003eBackground: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996).\u003cbr\u003e\nCatalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203).\u003cbr\u003e\nEnergy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996).\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu 392-Met 628\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 25.96 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 32 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083553210547,"sku":"PDEH100361-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_554425f1-83c0-4b9a-ba79-2e9bb5f14757.png?v=1708944552","url":"https:\/\/afsbio.com\/products\/recombinant-human-p-glycoprotein1-abcb1-protein-his-tag-pdeh100361","provider":"AFSBio Inc.","version":"1.0","type":"link"}