{"product_id":"recombinant-human-p21-protein-his-tag-pdeh100242","title":"Recombinant Human P21 protein (His tag) - PDEH100242","description":"\u003cp\u003eRecombinant Human P21 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEH100242-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: P21\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CAP20; CDK-interacting protein 1; CDKI; CDKN1; CDN1A; CIP1; CDKN1A; Cyclin Dependent Kinase Inhibitor 1A; DNA Synthesis Inhibitor; MDA-6; MDA6; Melanoma differentiation-associated protein 6; P21cip1; P21waf; PIC1; SDI1; SLC12A9; WAF1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P38936\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; Epigenetics and Nuclear Signaling; Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P38936\u003c\/p\u003e\n\n\u003cp\u003eBackground: May be the important intermediate by which p53\/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gly 40-Pro 164\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 13.64 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43072326697139,"sku":"PDEH100242-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d88f0d99-53bc-4adb-a5e6-54b41373ed1b.png?v=1708685663","url":"https:\/\/afsbio.com\/products\/recombinant-human-p21-protein-his-tag-pdeh100242","provider":"AFSBio Inc.","version":"1.0","type":"link"}