{"product_id":"recombinant-human-p4hb-protein-his-tag-pksh033399","title":"Recombinant Human P4HB Protein (His Tag) - PKSH033399","description":"\u003cp\u003eRecombinant Human P4HB Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033399-10, PKSH033399-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: P4HB\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB; Protein Disulfide-Isomerase; PDI; Cellular Thyroid Hormone-Binding Protein; Prolyl 4-Hydroxylase Subunit Beta; p55\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Tags \u0026amp; Cell Markers; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_000909.2\u003c\/p\u003e\n\n\u003cp\u003eBackground: Protein Disulfide-Isomerase (P4HB) is an endoplasmic reticulum lumen protein that belongs to the protein disulfide isomerase family. P4HB contains two thioredoxin domains and catalyzes the formation, breakage, and rearrangement of -S-S- bonds in proteins. P4HB is involved in hydroxylation of prolyl residues in preprocollagen. P4HB has the ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner. P4HB plays a role in both the influx and efflux of S-nitrosothiol-bound nitric oxide.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Asp18-Lys505\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 55.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 68 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149101072563,"sku":"PKSH033399-10","price":368.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149101105331,"sku":"PKSH033399-50","price":625.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_753cadb5-13c8-41ff-b340-a9aaba131211.png?v=1710340643","url":"https:\/\/afsbio.com\/products\/recombinant-human-p4hb-protein-his-tag-pksh033399","provider":"AFSBio Inc.","version":"1.0","type":"link"}