{"product_id":"recombinant-human-padi4-protein-his-tag-pksh032973","title":"Recombinant Human PADI4 Protein (His Tag) - PKSH032973","description":"\u003cp\u003eRecombinant Human PADI4 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032973-10, PKSH032973-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PADI4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; Protein-arginine Deiminase type IV; PADI4; PADI5; PDI5\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9UM07\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; epigenetics and nuclear signal; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9UM07\u003c\/p\u003e\n\n\u003cp\u003eBackground: Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination\/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Pro663\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 50mM Tris, 500mM NaCl, pH 7.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 76.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 78 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068783362227,"sku":"PKSH032973-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068783394995,"sku":"PKSH032973-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b068c955-390a-4e1e-a8b9-01fffb2dc07a.png?v=1708597599","url":"https:\/\/afsbio.com\/products\/recombinant-human-padi4-protein-his-tag-pksh032973","provider":"AFSBio Inc.","version":"1.0","type":"link"}