{"product_id":"recombinant-human-pancreasin-marapsin-prss27-protein-his-tagactive-pksh030900","title":"Recombinant Human Pancreasin\/Marapsin\/PRSS27 Protein (His Tag)(Active) - PKSH030900","description":"Recombinant Human Pancreasin\/Marapsin\/PRSS27 Protein (His Tag)(Active)\n\nSize: 50μg\n\nCatalogue Number: PKSH030900-50\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Pancreasin; Marapsin; PRSS27\n\nTarget Symptom: CAPH2; MPN; UNQ1884\/PRO4327\n\nResearch Area: Cell biology\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Enzyme\n\nFusion Tag: C-His\n\nUNIProt ID: Q9BQR3\n\nAccession: Q9BQR3\n\nBackground: The name \" Pancreasin\" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), which is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most strongly up-regulated protease in psoriatic lesions, where expression was localized to the upper region of the hyperplastic epidermis. Similarly, in the hyperproliferative epithelium of regenerating murine skin wounds, marapsin localized to the suprabasal layers, where keratinocytes undergo squamous differentiation. Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.\n\nActivity: Measured by its ability to cleave a colorimetric peptide substrate, NcarbobenzyloxyGlyArgThioBenzyl ester (ZGR-SBzl), in the presence of 5, 5’Dithiobis (2-nitrobenzoic acid) (DTNB). The specific activity is \u0026gt; 2000 pmols\/min\/μg.\n\nSequence: Met 1-Lys 290\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 30.9 kDa\n\nObserved MW: 42 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107260563635,"sku":"PKSH030900-50","price":1213.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0ee7b0d8-5175-4b01-b4ad-98f88ad6d735.png?v=1709382065","url":"https:\/\/afsbio.com\/products\/recombinant-human-pancreasin-marapsin-prss27-protein-his-tagactive-pksh030900","provider":"AFSBio Inc.","version":"1.0","type":"link"}