{"product_id":"recombinant-human-pcsk9-protein-his-tag-ha-avi-pksh032945","title":"Recombinant Human PCSK9 Protein (His Tag\/HA\/AVI) - PKSH032945","description":"\u003cp\u003eRecombinant Human PCSK9 Protein (His Tag\/HA\/AVI)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032945-20, PKSH032945-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PCSK9\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Proprotein Convertase Subtilisin\/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin\/Kexin-Like Protease PC9; PCSK9; NARC1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q8NBP7\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cell biology; Cardiovascular; Cancer; metabolism; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Biotinylated\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His-HA-AVI\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q8NBP7\u003c\/p\u003e\n\n\u003cp\u003eBackground: Human Proprotein Convertase Subtilisin\/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER; the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9\/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2); and play a role in the neural development.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln31-Gln152\u0026amp;Ser153-Gln692\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20%Glycerol, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 14\u0026amp;59\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18\u0026amp;70 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43068772647091,"sku":"PKSH032945-20","price":596.3,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43068772679859,"sku":"PKSH032945-100","price":1610.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d53919cf-d9be-44bf-9820-f085f7b4707c.png?v=1708597515","url":"https:\/\/afsbio.com\/products\/recombinant-human-pcsk9-protein-his-tag-ha-avi-pksh032945","provider":"AFSBio Inc.","version":"1.0","type":"link"}