{"product_id":"recombinant-human-pd-1-pdcd1-protein-c93s-mutant-his-tag-pksh032862","title":"Recombinant Human PD-1\/PDCD1 Protein (C93S Mutant, His Tag) - PKSH032862","description":"\u003cp\u003eRecombinant Human PD-1\/PDCD1 Protein (C93S Mutant, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032862-10, PKSH032862-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PD-1; PDCD1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Programmed cell death protein 1; PDCD1; PD-1; hPD-1; CD279; SLEB2; Hsle1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q15116\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; Cancer; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q15116\u003c\/p\u003e\n\n\u003cp\u003eBackground: Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28\/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-γ by suppressing the activation and transduction of PI3K\/AKT pathway. In addition; coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule; PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu25-Gln167; Cys93Ser\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 16.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 25-32 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068748366003,"sku":"PKSH032862-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068748398771,"sku":"PKSH032862-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_09e4ad4d-bad9-4a29-a35b-9c1296f0319f.png?v=1708597325","url":"https:\/\/afsbio.com\/products\/recombinant-human-pd-1-pdcd1-protein-c93s-mutant-his-tag-pksh032862","provider":"AFSBio Inc.","version":"1.0","type":"link"}