{"product_id":"recombinant-human-pfkfb1-protein-his-tag-pksh032459","title":"Recombinant Human PFKFB1 Protein (His Tag) - PKSH032459","description":"\u003cp\u003eRecombinant Human PFKFB1 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032459-10, PKSH032459-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PFKFB1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 6-phosphofructo-2-kinase\/fructose-2; 6-bisphosphatase 1; 6PF-2-K\/Fru-2; 6-P2ase liver isozyme; Fructose-2; 6-bisphosphatase; PFKFB1; F6PK; PFRX\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P16118\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cardiovascular; Neuroscience; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P16118\u003c\/p\u003e\n\n\u003cp\u003eBackground: 6-phosphofructo-2-kinase\/fructose-2, 6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2, 6-biphosphate using independent catalytic domains. It belongs to the phosphoglycerate mutase family. Fructose-2, 6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2, 6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser2-Tyr471\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 55.6 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43092781990067,"sku":"PKSH032459-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43092782022835,"sku":"PKSH032459-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7d97d2ac-b2e6-47d8-8cce-a0e4dd4856a7.png?v=1709119811","url":"https:\/\/afsbio.com\/products\/recombinant-human-pfkfb1-protein-his-tag-pksh032459","provider":"AFSBio Inc.","version":"1.0","type":"link"}