{"product_id":"recombinant-human-phosphomevalonate-kinase-pmvk-protein-his-tag-pksh032895","title":"Recombinant Human Phosphomevalonate Kinase\/PMVK Protein (His Tag) - PKSH032895","description":"\u003cp\u003eRecombinant Human Phosphomevalonate Kinase\/PMVK Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032895-10, PKSH032895-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PMVK\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Phosphomevalonate Kinase; PMKase; hPMK; PMVK; PMKI\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q15126\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q15126\u003c\/p\u003e\n\n\u003cp\u003eBackground: Phosphomevalonate kinase (PMVK) is a cytosolic enzyme. PMVK can be highly expressed in the heart, skeletal muscle, liver, pancreas, and kidney; it is expressed at lower levels in the brain, lung, and placenta. Induced by sterol, PMVK takes part in isopentenyl diphosphate biosynthesis through the mevalonate pathway. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Leu192\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 24.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 26 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068760195251,"sku":"PKSH032895-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068760228019,"sku":"PKSH032895-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8cf61660-ab5a-4790-8bbb-7450e52d16db.png?v=1708597408","url":"https:\/\/afsbio.com\/products\/recombinant-human-phosphomevalonate-kinase-pmvk-protein-his-tag-pksh032895","provider":"AFSBio Inc.","version":"1.0","type":"link"}