{"product_id":"recombinant-human-placenta-growth-factor-pgf-pigf-plgf-c-6his-pksh033937","title":"Recombinant Human Placenta Growth Factor\/PGF\/PIGF\/PLGF (C-6His) - PKSH033937","description":"\u003cp\u003eRecombinant Human Placenta Growth Factor\/PGF\/PIGF\/PLGF (C-6His)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033937-10, PKSH033937-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PGF; PIGF; PLGF\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PlGF2; PlGF-2; PGF; PLGF; PlGF2; PlGF; PGFL\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P49763\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P49763-3\u003c\/p\u003e\n\n\u003cp\u003eBackground: Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF\/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF forms containing 131 (PlGF-1), 152 (PlGF-2), and 203 (PlGF-3) amino acids (aa) respectively. PlGF is mainly found as a variably glycosylated, secreted, 55 - 60 kDa disulfide linked homodimer.The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PlGF (especially PlGF-1) and some forms of VEGF can form dimers that decrease the angiogenic effect of VEGF on VEGF R2. PlGF-2, like VEGF164\/165, shows heparin-dependent binding of neuropilin (Npn)-1 and Npn-2, and can inhibit nerve growth cone collapse. Circulating PlGF often correlates with tumor stage and aggressiveness, and therapeutic PlGF-2 antibodies are being investigated for their ability to inhibit tumor growth and angiogenesis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu19-Arg170\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 18.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 25-30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149126893747,"sku":"PKSH033937-10","price":420.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149126926515,"sku":"PKSH033937-50","price":1260.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5646ebf1-f37e-4e53-90e2-20a88aa520bf.png?v=1710341115","url":"https:\/\/afsbio.com\/products\/recombinant-human-placenta-growth-factor-pgf-pigf-plgf-c-6his-pksh033937","provider":"AFSBio Inc.","version":"1.0","type":"link"}