{"product_id":"recombinant-human-proenkephalin-b-pdyn-protein-his-tag-pksh033558","title":"Recombinant Human Proenkephalin-B\/PDYN Protein (His Tag) - PKSH033558","description":"\u003cp\u003eRecombinant Human Proenkephalin-B\/PDYN Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033558-10, PKSH033558-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Proenkephalin-B; PDYN\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: ADCA; PENKB; SCA23; PDYN; Dynorphin B; Big Dyn\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P01213\u003c\/p\u003e\n\n\u003cp\u003eAccession: P01213\u003c\/p\u003e\n\n\u003cp\u003eBackground: Proenkephalin-B(PDYN), belongs to the opioid neuropeptide precursor family. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and\/or processing. Leu-enkephalins, which is a type of Proenkephalin-B, compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Asp21-Ala254\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 27.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 35 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113969713331,"sku":"PKSH033558-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113969746099,"sku":"PKSH033558-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_cecc51c2-9c98-4c75-aa4e-381acfcf7ac5.png?v=1709549371","url":"https:\/\/afsbio.com\/products\/recombinant-human-proenkephalin-b-pdyn-protein-his-tag-pksh033558","provider":"AFSBio Inc.","version":"1.0","type":"link"}