{"product_id":"recombinant-human-psgl-1-cd162-protein-fc-tag-pksh033546","title":"Recombinant Human PSGL-1\/CD162 Protein (Fc Tag) - PKSH033546","description":"\u003cp\u003eRecombinant Human PSGL-1\/CD162 Protein (Fc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033546-10, PKSH033546-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PSGL-1; CD162\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG; CLA; PSGL1\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cardiovascular; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q14242\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q14242\u003c\/p\u003e\n\n\u003cp\u003eBackground: PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, especially rolling adhesion of leukocytes to vascular endothelium. Through high affinity, This SLe(x)-type proteoglycanPGSL-1 calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln42-Gly295\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 52.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: \u0026gt;170 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113968337075,"sku":"PKSH033546-10","price":155.4,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113968369843,"sku":"PKSH033546-50","price":415.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8733a57f-1576-4e0c-aede-1be44bee9a06.png?v=1709549352","url":"https:\/\/afsbio.com\/products\/recombinant-human-psgl-1-cd162-protein-fc-tag-pksh033546","provider":"AFSBio Inc.","version":"1.0","type":"link"}